Drugs and Their Biological Targets by Campos Rosa Joaquín M. Camacho Quesada M. Encarnación

Author:Campos Rosa, Joaquín M.,Camacho Quesada, M. Encarnación [Неизв.]
Language: eng
Format: epub
Publisher: De Gruyter
Published: 2018-08-02T21:00:00+00:00

6.2.3Multiple analgesic receptors

6.2.3.1Mu receptor (μ)

Morphine binds strongly to this receptor and produces analgesia. Binding to this receptor also leads to the undesirable effects of respiratory depression, euphoria and addiction.

6.2.3.2Kappa receptor (κ)

The bond strength is less than that of the μ-receptor. The biological response is analgesia with sedation and none of the dangerous side effects. It is this receptor that provides the best hopes for safe analgesia. The results obtained with nalorphine, pentazocine and buprenorphine can now be understood. These compounds act as antagonists at the μ-receptor, blocking morphine. However, they act as weak agonists at the μ-receptor. Unfortunately, they present hallucinogenic side effects as a result of binding to a completely different receptor in the brain called the σ-receptor, where they act as agonists.

Download

Copyright Disclaimer:
This site does not store any files on its server. We only index and link to content provided by other sites. Please contact the content providers to delete copyright contents if any and email us, we'll remove relevant links or contents immediately.